Infertility affects 1 in 6 couples worldwide, and male factor issues account for up to 55% of cases—yet most preconception advice still focuses only on women. The shift from prenatal vitamins to true preconception optimization is here, and couples who optimize together see better outcomes.
At Progeny Brands, we believe fertility is a team sport at the cellular level. That’s why our liposomal spermidine, liposomal CoQ10, and NAC combination targets the primary roadblocks for both partners: oxidative stress, mitochondrial decline, and impaired autophagy. This isn’t another “his and hers” bundle of generic multivitamins. It’s a science-backed, autophagy-optimized protocol designed for preconception success—whether you’re trying naturally or preparing for IVF.
If you’re in the TTC (trying to conceive) community, over 35, or simply want the healthiest eggs and sperm possible, read on. Couples who align on cellular-level support give their future baby the best possible start.
Why Most “His & Hers” Fertility Supplements Fall Short
Walk down any supplement aisle or scroll TTC forums and you’ll see dozens of fertility supplements for couples. Most are repackaged prenatals: folate for her, zinc for him, maybe some CoQ10 or omega-3s sprinkled in.
The problem? They treat symptoms, not root causes.
- Women 30-39+: Egg quality declines rapidly after 35 due to mitochondrial dysfunction and accumulated oxidative damage. Follicle development takes ~90 days—yet most women start supplements only after they’re already “trying.”
- Men 30-45: Sperm regenerates every ~74 days. Oxidative stress damages DNA, motility, and morphology in up to 80% of infertile men, yet male factor infertility remains under-discussed.
Traditional prenatals were designed for pregnancy, not preconception optimization. They miss the cellular renewal process that powers healthy conception: autophagy (your body’s natural recycling system) and mitophagy (targeted mitochondrial cleanup).
That’s where Progeny’s targeted combination shines.
Learn the science of preconception vs. prenatal vitamins →
The Three Primary Roadblocks for Couples—and How Our Autophagy Formulation Crushes Them
1. Oxidative Stress: The Hidden Saboteur Reactive oxygen species (ROS) damage eggs, sperm DNA, and embryos. Studies show elevated oxidative stress markers in the majority of infertile couples.
NAC (N-Acetyl Cysteine) is a glutathione precursor and potent ROS scavenger. Research on infertile couples demonstrates NAC improves sperm concentration, motility, and morphology in men while supporting ovulation and reducing insulin resistance in women with PCOS. When combined with other antioxidants, it significantly boosts semen parameters and lowers lipid peroxidation.
2. Mitochondrial Decline: Energy Crisis in Reproductive Cells Eggs and sperm are energy hogs. Aging mitochondria produce less ATP and more ROS, leading to poor egg quality and sluggish sperm.
Liposomal CoQ10 is the gold-standard mitochondrial cofactor. A 2020 meta-analysis of randomized trials found CoQ10 supplementation in women undergoing ART increased clinical pregnancy rates (28.8% vs. 14.1%) and improved oocyte retrieval, fertilization rates, and high-quality embryo numbers—especially in poor ovarian responders and PCOS patients. In men, CoQ10 consistently improves sperm motility, concentration, and reduces DNA fragmentation.
3. Impaired Autophagy & Mitophagy: The Cellular Renewal Gap Autophagy clears damaged cellular components—critical for high-quality gametes. Spermidine levels naturally decline with age, directly impacting oocyte and sperm health.
Liposomal Spermidine is the autophagy superstar. Peer-reviewed research shows spermidine supplementation rejuvenates oocyte quality in aged models by enhancing mitophagy, restoring mitochondrial function, and reducing follicular atresia and oxidative stress in ovarian tissue. In males, it improves sperm motility, morphology, protects DNA, and rescues testicular dysfunction.
Why Liposomal Delivery Is Non-Negotiable for True Bioavailability
Regular spermidine and CoQ10 have poor absorption—much of the dose is destroyed in the gut. Progeny’s liposomal technology encapsulates these compounds in phospholipid spheres that mimic cell membranes. This delivers dramatically higher cellular uptake so the active ingredients actually reach your eggs, sperm, and mitochondria.
Compare liposomal vs. regular spermidine here
The Autophagy Optimized Conception Protocol for Couples: 90 Days of Cellular Synergy
Our liposomal spermidine + liposomal CoQ10 + NAC formulation is designed for simultaneous use by both partners. Why 90 days?
- Matches the full spermatogenesis cycle (~74 days) plus buffer
- Aligns with ovarian follicle maturation (~90 days)
- Gives autophagy time to clear cellular debris and rebuild mitochondrial health
Daily Couple Protocol Highlights:
- Morning: Liposomal spermidine (triggers autophagy/mitophagy for both partners)
- With meals: Liposomal CoQ10 (mitochondrial energy support)
- Evening or as directed: NAC (ongoing oxidative stress defense)
Couples following the full protocol report feeling more energized, notice cycle improvements, and see measurable improvements in semen analysis parameters after 90 days—exactly when it matters most.
Download the full Autophagy Optimized Conception Protocol
Real Science, Real Results: Backed by Studies
- Spermidine restores oocyte quality via mitophagy and protects against ovarian aging (multiple NIH/PubMed studies).
- CoQ10 doubles clinical pregnancy odds in ART cycles for women over 35.
- Antioxidant combos including NAC and CoQ10 improve sperm parameters and reduce DNA fragmentation in male factor infertility.
- 70% of IVF patients already use supplements—yet 45% never tell their doctors. Our clean, science-first formula is IVF-clinic compatible and physician-discreet.
Why This Combination Beats Separate “His” and “Hers” Products
Most fertility supplements for couples ‘bundles’ are just two separate formulas in one box. Progeny’s approach is different: shared cellular mechanisms (autophagy, mitophagy, oxidative stress defense) delivered in highly bioavailable liposomal form. One convenient protocol. One powerful synergy. Lower cost than separate premium brands and far more targeted than broad-spectrum prenatals.
Whether you’re a career-focused woman 35-45 optimizing egg quality, a man supporting sperm health, or both preparing for IVF, this protocol complements clinical care without interference.
See our full line of preconception products
Ready to Optimize Together?
Fertility isn’t 50/50—it’s 100/100 at the cellular level. Stop guessing with generic vitamins. Start with the only supplement line purpose-built for autophagy-driven preconception optimization for both men and women.
Take the 90-Day Challenge as a couple and give your embryos the healthiest possible foundation.
Progeny Brands — Fertility optimized at the cellular level.